Pairwise comparisons in the analysis of carcinogenicity data

نویسندگان

  • Mohammad A. Rahman
  • Ram C. Tiwari
چکیده

Analysis of carcinogenicity data generally involves a trend test across all dose groups and a pairwise comparison of the high dose group with the control. The most commonly used test for a positive trend is the Cochran-Armitage test. This test is asymptotically normal. For the pairwise comparison of the high dose group with the control group, we propose two modifications: the first modification is to apply the test on the data from high dose and control groups after dropping the data from the low and the medium dose groups; the second modification is to adjust the test conditional on data from all dose groups. We compare the power performance of these two modifications for the pairwise comparisons.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Statistical issues in the design, analysis and interpretation of animal carcinogenicity studies.

Statistical issues in the design, analysis and interpretation of animal carcinogenicity studies are discussed. In the area of experimental design, issues that must be considered include randomization of animals, sample size considerations, dose selection and allocation of animals to experimental groups, and control of potentially confounding factors. In the analysis of tumor incidence data, sur...

متن کامل

A Common Weight Multi-criteria Decision analysis-data Envelopment Analysis Approach with Assurance Region for Weight Derivation from Pairwise Comparison Matrices

Deriving weights from a pairwise comparison matrix (PCM) is a subject for which a wide range of methods have ever been presented. This paper proposes a common weight multi criteria decision analysis-data envelopment analysis (MCDA-DEA) approach with assurance region for weight derivation from a PCM. The proposed model has several merits over the competing approaches and removes the drawbacks of...

متن کامل

Genetic Diversity of Iranian and Some of European Grapesrevealed by Microsatellite Markers

In order to characterize Iranian grape (Vitis vinifera L.) germplasm, 136 genotypes were collected from five grape growing regions (Azarbaijan, Qazvin, Kordestan, Khorasan and Fars) and genotyped along with 36 European cultivars using 9 sequence tagged microsatellite sites (STMS) markers. The used set of markers could distinguish all 172 genotypes under study. Altogether 84 polymorphic alleles ...

متن کامل

Determination of weight vector by using a pairwise comparison matrix based on DEA and Shannon entropy

The relation between the analytic hierarchy process (AHP) and data envelopment analysis (DEA) is a topic of interest to researchers in this branch of applied mathematics. In this paper, we propose a linear programming model that generates a weight (priority) vector from a pairwise comparison matrix. In this method, which is referred to as the E-DEAHP method, we consider each row of the pairwise...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2013